Genomics

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Micro-RNA expression profiles in upper tract urothelial carcinoma differentiate stage and tumor progression: screening data


ABSTRACT: Accurate grading and staging of upper tract urothelial carcinoma (UTUC) often proves challenging, and improved knowledge of tumor biology could identify patients who are candidates for minimally invasive therapy rather than nephroureterectomy (NU). Total RNA was extracted from formalin-fixed, paraffin-embedded NU samples. Thirty-five samples with diverse pathologies were selected and screened via microRNA RT-qPCR array for 752 unique miRNA. Validation of differentially expressed miRNA was performed on 123 additional NU tissue specimens from two institutions. The data presented in this series are for the 35 samples analyzed in the screening analysis. The data was normalized to the global mean of each sample using microRNA detected in all samples with a Cq<37.

ORGANISM(S): synthetic construct Homo sapiens

PROVIDER: GSE119601 | GEO | 2019/01/01

REPOSITORIES: GEO

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