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Whole Genome Bisulfite Sequencing of Rett Syndrome and Control Human BA9 Cortex

ABSTRACT: Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by mutations in the gene encoding methyl CpG binding protein 2 (MeCP2) that occur sporadically in 1:10,000 female births. RTT is characterized by a period of largely normal development followed by regression in language and motor skills at 6-18 months of age. To investigate alterations in DNA methylation in RTT, we performed whole genome bisulfite sequencing on brodmann area 9 of human cortex from RTT and matched controls.

ORGANISM(S): Homo sapiens

PROVIDER: GSE119980 | GEO | 2019/09/17

REPOSITORIES: GEO

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