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Monocyte-derived alveolar macrophages induced by influenza infection confer long-term antibacterial protection

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE120543 | GEO | 2020/01/13

REPOSITORIES: GEO

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Monocyte-derived alveolar macrophages induced by influenza infection confer long-term antibacterial protection [RNA-seq]

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Monocyte-derived alveolar macrophages induced by influenza infection confer long-term antibacterial protection [ATAC-seq]

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Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection.

Project description:Despite the prevalence and clinical importance of influenza, its long-term effect on lung immunity is unclear. Here we describe that following viral clearance and clinical recovery, at 1 month after infection with influenza, mice are better protected from Streptococcus pneumoniae infection due to a population of monocyte-derived alveolar macrophages (AMs) that produce increased interleukin-6. Influenza-induced monocyte-derived AMs have a surface phenotype similar to resident AMs but display a unique functional, transcriptional and epigenetic profile that is distinct from resident AMs. In contrast, influenza-experienced resident AMs remain largely similar to naive AMs. Thus, influenza changes the composition of the AM population to provide prolonged antibacterial protection. Monocyte-derived AMs persist over time but lose their protective profile. Our results help to understand how transient respiratory infections, a common occurrence in human life, can constantly alter lung immunity by contributing monocyte-derived, recruited cells to the AM population.

| S-EPMC6983324 | biostudies-literature

Monocyte-derived alveolar macrophages induced by influenza infection confer long-term antibacterial protection

Project description:Monocyte-derived alveolar macrophages induced by influenza infection confer long-term antibacterial protection

| PRJNA493387 | ENA

Monocyte-derived alveolar macrophages induced by influenza infection confer long-term antibacterial protection [RNA-seq]

Project description:Monocyte-derived alveolar macrophages induced by influenza infection confer long-term antibacterial protection [RNA-seq]

| PRJNA493458 | ENA

Monocyte-derived alveolar macrophages induced by influenza infection confer long-term antibacterial protection [ATAC-seq]

Project description:Monocyte-derived alveolar macrophages induced by influenza infection confer long-term antibacterial protection [ATAC-seq]

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Monocyte-derived alveolar macrophages induced by influenza infection confer long-term antibacterial protection [ATAC-seq 2]

Project description:Monocyte-derived alveolar macrophages induced by influenza infection confer long-term antibacterial protection [ATAC-seq 2]