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Monocyte-derived alveolar macrophages induced by influenza infection confer long-term antibacterial protection

ABSTRACT: Monocyte-derived alveolar macrophages induced by influenza infection confer long-term antibacterial protection

PROVIDER: PRJNA493387 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7906940_1.fastq.gz	Fastqsanger.gz
	SRR7906940_2.fastq.gz	Fastqsanger.gz
	SRR7909000.fastq.gz	Fastqsanger.gz
	SRR7909010.fastq.gz	Fastqsanger.gz
	SRR7906941_1.fastq.gz	Fastqsanger.gz

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Monocyte-derived alveolar macrophages induced by influenza infection confer long-term antibacterial protection [ATAC-seq]

Project description:Monocyte-derived alveolar macrophages induced by influenza infection confer long-term antibacterial protection [ATAC-seq]

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Monocyte-derived alveolar macrophages induced by influenza infection confer long-term antibacterial protection [RNA-seq]

Project description:Monocyte-derived alveolar macrophages induced by influenza infection confer long-term antibacterial protection [RNA-seq]

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Monocyte-derived alveolar macrophages induced by influenza infection confer long-term antibacterial protection [RNA-seq 2]

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Monocyte-derived alveolar macrophages induced by influenza infection confer long-term antibacterial protection [ATAC-seq 2]

Project description:Monocyte-derived alveolar macrophages induced by influenza infection confer long-term antibacterial protection [ATAC-seq 2]

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Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection.

Project description:Despite the prevalence and clinical importance of influenza, its long-term effect on lung immunity is unclear. Here we describe that following viral clearance and clinical recovery, at 1 month after infection with influenza, mice are better protected from Streptococcus pneumoniae infection due to a population of monocyte-derived alveolar macrophages (AMs) that produce increased interleukin-6. Influenza-induced monocyte-derived AMs have a surface phenotype similar to resident AMs but display a unique functional, transcriptional and epigenetic profile that is distinct from resident AMs. In contrast, influenza-experienced resident AMs remain largely similar to naive AMs. Thus, influenza changes the composition of the AM population to provide prolonged antibacterial protection. Monocyte-derived AMs persist over time but lose their protective profile. Our results help to understand how transient respiratory infections, a common occurrence in human life, can constantly alter lung immunity by contributing monocyte-derived, recruited cells to the AM population.

| S-EPMC6983324 | biostudies-literature

Monocyte-derived alveolar macrophages induced by influenza infection confer long-term antibacterial protection

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-01-13 | GSE120543 | GEO

Monocyte-derived alveolar macrophages induced by influenza infection confer long-term antibacterial protection [RNA-seq]

Project description:To investigate transcriptomic differences using RNA-seq in macrophages from a BM origin (CD45.1) and embryonic origin (CD45.2) in influenza-experienced, and naive lungs - at baseline and following stimulation

2020-01-13 | GSE120542 | GEO

Monocyte-derived alveolar macrophages induced by influenza infection confer long-term antibacterial protection [ATAC-seq]

Project description:To investigate differences in the chromatin accessibility using ATAC-seq. This was done in macrophages from a BM origin (CD45.1) and embryonic origin (CD45.2) in influenza-experienced, and naive lungs - at baseline and following Pam3CSK4 stimulation

2020-01-13 | GSE120540 | GEO

Monocyte-derived alveolar macrophages induced by influenza infection confer long-term antibacterial protection [RNA-seq 2]

Project description:To investigate transcriptomic differences using RNA-seq. This was done in macrophages isolated from a busulfan chimera, using congenic markers (CD45.1 for a BM origin, and CD45.2 for a host origin) in influenza-experienced, and naive lungs - at baseline and following Pam3CSK4 stimulation

2020-01-13 | GSE131252 | GEO

Monocyte-derived alveolar macrophages induced by influenza infection confer long-term antibacterial protection [ATAC-seq 2]

Project description:To investigate differences in the chromatin accessibility using ATAC-seq. This was done in macrophages isolated from a busulfan chimera, using congenic markers (CD45.1 for a BM origin, and CD45.2 for a host origin) in influenza-experienced, and naive lungs - at baseline and following Pam3CSK4 stimulation

2020-01-13 | GSE131251 | GEO

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