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Combination immunotherapy can rescue CD8+ T cell dysfunction and maintain memory phenotype in cancer

ABSTRACT: In this study we unveiled specific molecular and cellular mechanisms driving the potent synergism of a coinhibitory antagonist (anti-PD-1 Ab) and a costimulatory agonist (anti-GITR Ab), a modality currently in early clinical testing, and elucidated the parameters required for durable anti-tumor responses.

ORGANISM(S): Mus musculus

PROVIDER: GSE120909 | GEO | 2018/11/02

REPOSITORIES: GEO

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RNA-seq analysis of mouse esophageal tissue following GITR agonism in a model of esophageal squamous cell cancer

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