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Oligodendrocyte progenitor cells become regionally diverse and heterogeneous with age

ABSTRACT: Oligodendrocyte progenitor cells (OPCs), which differentiate into myelinating oligodendrocytes during central nervous system (CNS) development, are the main proliferative cells in the adult brain. OPCs are conventionally considered a homogeneous population, particularly with respect to their electrophysiological properties, but this has been debated. We show, by using single-cell electrophysiological recordings, that OPCs start out as a homogeneous population, but become functionally heterogeneous, varying both within and between brain regions and with age. These electrophysiological changes in OPCs correlate with the differentiation potential of OPCs; thus, they may underlie the differentiational differences in OPCs between regions and likewise differentiation failure with age.

ORGANISM(S): Mus musculus

PROVIDER: GSE121083 | GEO | 2019/01/15

REPOSITORIES: GEO

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Oligodendrocyte progenitor cells become regionally diverse and heterogeneous with age

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