Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA sequencing analysis of necroptosis related genes in TBZ treated HT-29 cells.

ABSTRACT: Analysis of necroptosis-induced changes in gene expression patterns from HT-29 cells

ORGANISM(S): Homo sapiens

PROVIDER: GSE121149 | GEO | 2019/12/31

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

RNA sequencing analysis of necroptosis related genes in TBZ treated HT-29 cells.

Project description:RNA sequencing analysis of necroptosis related genes in TBZ treated HT-29 cells.

| PRJNA495849 | ENA

HT-29 cells treated with IFN-γ

Project description:Expression data from HT-29 human colon adenocarcinoma cells treated with IFN-γ for 24 hr

2013-08-06 | GSE38516 | GEO

HT-29 cells treated with IFN-γ

Project description:Expression data from HT-29 human colon adenocarcinoma cells treated with IFN-γ for 24 hr Total RNA was isolated from HT-29 cells after 24h stimulation with 200 U ml-1 IFN-γ (Roche). The experiment was done on three biological replicates.

2013-08-06 | E-GEOD-38516 | biostudies-arrayexpress

HT-29 treated with mature fragilysin LC-MSMS

Project description:Fragilysin is a protein secreted by toxigenic Bacteroides fragilis strains. Fragilysin has a motive HEXXHXXGXXH, which is a zinc-binding motif found in metalloproteinases clan termed metzincins. In this study we obtained all three known recombinant fragilysin isoforms in Escherichia coli and tested its activity. We detected no cleavage of gelatin and chromogenic substrates (such as azocoll and azocasein) by all isoforms. We demonstrated that treatment of HT-29 cells with fragilysins caused E-cadherin cleavage, nevertheless cleavage of recombinant E-cadherins was not observe as well as E-cadherin in isolated cell fractions. It was shown that the native structure of active site characteristic for metalloproteinases is necessary for fragilysin biologic activity. We detected proteins that are released in cultural medium after HT-29 cells treatment with fragilysin. These proteins are potential substrates for fragilysin.

2015-05-26 | PXD001271 | Pride

Expression data of colorectal cancer HT-29 cells

Project description:Colorectal cancer HT-29 cell line is a comonly-used human cancer cell line. We have used this cell line for examining the effect of various anticancer compounds on gene expression and we obtained gene expression data of untreated HT-29 cells as a control data for the analysis.

2017-06-14 | GSE99968 | GEO

Bevacizumab-resistant HT-29 tumors vs untreated control

Project description:Gene expression of bevacizumab-resistant HT-29 tumors vs untreated control

2016-09-08 | GSE86525 | GEO

Folic Acid study in HT-29 cells

Project description:Low intracellular folate levels diminish the growth rate of HT-29 human colon cancer cells. This is accompanied by a metabolic shift from cytosolic glycolysis towards mitochondrial oxidative phosphorylation, as demonstrated by a lower lactate production and an increased mitochondrial oxygen consumption rate. To obtain insight in the molecular effects underlying these changes, the steady state gene expression profiles of HT-29 cells with different intracellular folate concentrations were compared. The gene expression profile of HT-29 cells with low intracellular folate levels (grown for 3 weeks in 10 ng/ml folic acid (PGA)) was clearly distinct from that of the other exposure conditions, which provide sufficient intracellular folate levels (100 ng/ml PGA, 10 ng/ml methyltetrahydrofolate (MTHF) or 100 ng/ml MTHF). Intracellular folate deficiency, contrary to expectation, did not lead to major changes in expression of genes involved in energy metabolism. This suggests that the shift towards mitochondrial oxidative phosphorylation is not mediated at the transcription level. Furthermore, only minor changes in the expression of folate metabolism related genes were observed. The changes that were observed were consistent with nucleotide salvage and in agreement with nucleotide need of the slow-growing folate-deficient HT-29 cells. The major observed effects were on cell cycle related gene expression, which was increased and interferon-responsive gene expression, which was reduced. The increase in cell cycle related gene expression seems compensatory to the reduced cell growth. Down-regulation of the interferon-response may be explained by decreased expression of signal transducer and activator of transcription 1 upon folate deficiency. Keywords: dose response, folic acid, HT-29 cells, human

2005-08-13 | GSE3099 | GEO

Peripheral regions and central regions from HT-29 tumors

Project description:Gene expression of peripheral regions and central regions from HT-29 tumors

2015-01-10 | GSE64831 | GEO

Effect of sodium butyrate on colorectal cancer cell line HT-29

Project description:Analysis of colorectal cancer (CRC) cell line HT-29 treated with Sodium Butyrate. Sodium Butyrate, a HDAC inhibitor present in gut, can differentiate the undifferentiated HT-29 to enterocytes by the induction of brush border enzyme alkaline phosphatase. Results provide the transcriptional profiling underlying the butyrate-induced differentiation of CRC.

2016-12-31 | GSE61429 | GEO

Identify genes modulated by gemcitabine and/or GNE-783 in HT-29 tumors in vivo

Project description:Identified genes that were up- or down-regulated in HT-29 xenograft tissue in response to the indicated treatments.

2017-09-01 | GSE61802 | GEO