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A novel animal model for secondary progressive multiple sclerosis by oligodendroglia-specific conditional connexin 47 knockout [Affy]

ABSTRACT: Objective: To elucidate the role of Cx47 loss in chronic neuroinflammation and establish an SPMS model. Methods: Plp-CreERT; Cx47fl/fl mice were generated and administered tamoxifen to induce oligodendroglia-specific conditional knockout of Cx47 (Cx47 icKO). Ten days after tamoxifen treatment, Cx47 icKO mice and their control littermates were immunized by myelin oligodendrocyte glycoprotein peptide 35-55 to induce experimental autoimmune encephalomyelitis (EAE).

ORGANISM(S): Mus musculus

PROVIDER: GSE121337 | GEO | 2018/10/17

REPOSITORIES: GEO

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A novel animal model for secondary progressive multiple sclerosis by oligodendroglia-specific conditional connexin 47 knockout [Agilent]

Project description:Objective: To elucidate the role of Cx47 loss in chronic neuroinflammation and establish an SPMS model. Methods: Plp-CreERT; Cx47fl/fl mice were generated and administered tamoxifen to induce oligodendroglia-specific conditional knockout of Cx47 (Cx47 icKO). Ten days after tamoxifen treatment, Cx47 icKO mice and their control littermates were immunized by myelin oligodendrocyte glycoprotein peptide 35-55 to induce experimental autoimmune encephalomyelitis (EAE).

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