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RNA-seq of bulk Treg and Tconv cells from murine liver and lymphoid tissues

ABSTRACT: With the aim of understanding how Treg cells in highly vascularized tissues are related to Treg cells in other organs, we performed RNA-seq analysis of bulk Treg and Tconv cells isolated from liver, blood, spleen, and the liver-draining portal lymph node. This revealed a clear separation of cell transcriptomes by both tissue and Treg/Tconv identity, with cells from the liver falling between blood- and spleen-derived cells. Compared to splenic Treg cells, hepatic Treg cells were enriched for genes related to proliferation and activation, and genes encoding chemokine and cytokine receptors.

ORGANISM(S): Mus musculus

PROVIDER: GSE121480 | GEO | 2018/10/22

REPOSITORIES: GEO

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