Transcriptomics

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A Small Molecule Activator of the TET2 Tumor Suppressor


ABSTRACT: TET2 protein is a dioxygenase that oxidizes 5-methylcytosine and is responsible for DNA demethylation. We found that a small molecule drug (3FM-dC) activates the enzyme activity of TET2. The sequencing data suggest that 3FM-dC induced global changes in DNA hydroxymethylation and gene expression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE121506 | GEO | 2022/10/18

REPOSITORIES: GEO

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