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Intestinal toxicity in rats following administration of CDK4/6 inhibitors is independent of primary pharmacology

ABSTRACT: Male Sprague Dawley rats (CRL/CD SD, Charles River Laboratories, Hollister, CA) 6-8 weeks-old were utilized. We used microarrays to analyze changes in gene expression in gastrointestinal tissue (musocal scrapings) after 4 days of dosing. Total RNA was extracted from tissues of 3 rats per experimental group for analysis.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE121695 | GEO | 2018/11/07

REPOSITORIES: GEO

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