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Tumor region-specific microarray analysis according to trastuzumab distribution in breast cancer patient derived xenograft

ABSTRACT: Our novel drug imaging technique revealed that trastuzumab, which is representative antibody drug for breast and gastric cancer in clinical, distributed heterogeneously inside tumor even though its target receptor, HER2 (Human epidermal growth factor receptor 2) expressed homogeneously. For identifying a predominant regulator of trastuzumab tumor delivery in the tumor site, we tried tumor region-specific microarray analysis according to trastuzumab distribution in patient derived xenograft model.

ORGANISM(S): Homo sapiens

PROVIDER: GSE121787 | GEO | 2019/11/01

REPOSITORIES: GEO

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RNA sequencing of BT474 cells treated with trastuzumab or trastuzumab + pertuzumab and BT474-derived cells resistant to trastuzumab or trastuzumab + pertuzumab

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