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Mesenchymal transition and acquired therapy resistance of glioblastoma cells is connected to astrocyte reactivity

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE122809 | GEO | 2020/11/30

REPOSITORIES: GEO

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Mesenchymal transition and acquired therapy resistance of glioblastoma cells is connected to astrocyte reactivity (DNA methylation data set)

Project description:We show that Glioma initiating cells (GICs) can, through MES transition, enter a reactive-astrocyte-like cell state which is connected to increased therapy resistance

2020-11-30 | GSE122808 | GEO

Mesenchymal transition and acquired therapy resistance of glioblastoma cells is connected to astrocyte reactivity (Affymetrix HTA 2.0 data set)

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Mesenchymal transition and acquired therapy resistance of glioblastoma cells is connected to astrocyte reactivity

Project description:Mesenchymal transition and acquired therapy resistance of glioblastoma cells is connected to astrocyte reactivity

| PRJNA506413 | ENA

Mesenchymal transition and acquired therapy resistance of glioblastoma cells is connected to astrocyte reactivity (DNA methylation data set)

Project description:Mesenchymal transition and acquired therapy resistance of glioblastoma cells is connected to astrocyte reactivity (DNA methylation data set)

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Mesenchymal transition and acquired therapy resistance of glioblastoma cells is connected to astrocyte reactivity (Affymetrix HTA 2.0 data set)

Project description:Mesenchymal transition and acquired therapy resistance of glioblastoma cells is connected to astrocyte reactivity (Affymetrix HTA 2.0 data set)

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Epithelial-mesenchymal transition and acquired resistance to ALK inhibitors

Project description:This SuperSeries is composed of the SubSeries listed below.

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A Proneural to Mesenchymal Transition Mediated by NFkB Promotes Radiation Resistance in Glioblastoma

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Project description:This SuperSeries is composed of the SubSeries listed below.

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Acquired platinum resistance involves epithelial to mesenchymal transition through ubiquitin ligase FBXO32 dysregulation.

Project description:To identify the molecules involved in epithelial to mesenchymal transition (EMT) in urothelial carcinoma (UC) after acquisition of platinum resistance, here we examined the changes in global gene expression before and after platinum treatment. Four invasive UC cell lines, T24, 5637, and their corresponding sublines T24PR and 5637PR with acquired platinum resistance, were assessed by microarray, and the ubiquitin E3 ligase FBXO32 was newly identified as a negative regulator of EMT in UC tumors after acquisition of platinum resistance. In vitro and in vivo studies showed an intimate relationship between FBXO32 expression and EMT, demonstrating that FBXO32 dysregulation in T24PR cells results in elevated expression of the mesenchymal molecules SNAIL and vimentin and decreased expression of the epithelial molecule E-cadherin. The association between FBXO32 expression and EMT was further validated using clinical samples. Knockdown of MyoD expression, a specific target of FBXO32 polyubiquitination, revealed upregulation of E-cadherin expression and downregulation of SNAIL and vimentin expression in T24PR cells. Comparative genomic hybridization array analysis demonstrated loss of heterozygosity at 8q24.13 in T24PR cells, which harbors FBXO32. Our findings suggest the importance of the association between EMT and ubiquitin-proteasome regulation when tumors develop acquired platinum resistance.

| S-EPMC5085609 | biostudies-literature

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