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Mediator12 and 13 act as conditional anti-silencing factors in Arabidopsis

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Arabidopsis thaliana

PROVIDER: GSE123563 | GEO | 2020/12/31

REPOSITORIES: GEO

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Mediator12 and 13 act as conditional anti-silencing factors in Arabidopsis [ChIP-seq]

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Mediator12 and 13 act as conditional anti-silencing factors in Arabidopsis [RNA-seq]

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Mediator12 and 13 act as conditional anti-silencing factors in Arabidopsis

Project description:Mediator12 and 13 act as conditional anti-silencing factors in Arabidopsis

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Mediator12 and 13 act as conditional anti-silencing factors in Arabidopsis [ChIP-seq]

Project description:Mediator12 and 13 act as conditional anti-silencing factors in Arabidopsis [ChIP-seq]

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Mediator12 and 13 act as conditional anti-silencing factors in Arabidopsis [RNA-seq]

Project description:Mediator12 and 13 act as conditional anti-silencing factors in Arabidopsis [RNA-seq]

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The characterization of Mediator12 and 13 as conditional positive gene regulators in Arabidopsis

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-04-29 | GSE143835 | GEO

The characterization of Mediator12 and 13 as conditional positive gene regulators in Arabidopsis [RNA-seq]

Project description:Mediator is a multi-protein complex which facilitates the initial steps of gene transcription. Mediator 12 (MED12) and MED13 are components of a module that reversibly associates with the core Mediator complex, and both positively and negatively regulates gene expression. Here, in an Arabidopsis mutant screen for factors required for morc1 de-repressed gene expression, we identified MED12 and MED13 as positive gene regulators, both of which contribute broadly to morc1 de-repressed gene expression. Both MED12 and MED13 are preferentially required for the expression of genes lacking active chromatin marks, a chromatin signature shared with morc1 re-activated loci. We further discovered that MED12 tends to interact with genes that are responsive to environmental stimuli, including light and radiation. We demonstrate that the light-induced transient gene expression depends on MED12, and is accompanied by a concomitant increase in MED12 enrichment during induction. In contrast, the steady-state expression level of these genes showed little dependence on MED12, suggesting that MED12 is primarily required to aid the expression of genes in transition from non-active to active states.

2020-04-29 | GSE143833 | GEO

The characterization of Mediator12 and 13 as conditional positive gene regulators in Arabidopsis [ChIP-seq]

2020-04-29 | GSE143831 | GEO

Anti-silencing mutants

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-10-11 | GSE74349 | GEO

Arabidopsis proteins with a transposon-related domain act in gene silencing.

Project description:Transposable elements (TEs) are prevalent in most eukaryotes, and host genomes have devised silencing strategies to rein in TE activity. One of these, transcriptional silencing, is generally associated with DNA methylation and short interfering RNAs. Here we show that the Arabidopsis genes MAIL1 and MAIN define an alternative silencing pathway independent of DNA methylation and short interfering RNAs. Mutants for MAIL1 or MAIN exhibit release of silencing and appear to show impaired condensation of pericentromeric heterochromatin. Phylogenetic analysis suggests not only that MAIL1 and MAIN encode a retrotransposon-related plant mobile domain, but also that host plant mobile domains were captured by DNA transposons during plant evolution. Our results reveal a role for Arabidopsis proteins with a transposon-related domain in gene silencing.

| S-EPMC5418596 | biostudies-literature

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