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Genome-wide analysis of H3K79 dimethylation in MLL-AF4 leukemic bone marrow

ABSTRACT: We created a mouse model where conditional expression of physiologic levels of an Mll-AF4 fusion oncogene induces development of acute lymphoblastic (ALL) or acute myeloid leukemias (AML). ChIP-chip analysis demonstrated increased histone H3 Lysine 79 (H3K79) dimethylation that correlated with Mll-AF4 associated gene expression profiles in murine ALLs, and in human MLL-rearranged leukemias. In addition, human MLL-rearranged ALLs can be distinguished from other ALLs by their genome-wide H3K79 methylation profiles. Keywords: Cell type comparison

ORGANISM(S): Mus musculus

PROVIDER: GSE12362 | GEO | 2008/11/04

SECONDARY ACCESSION(S): PRJNA114201

REPOSITORIES: GEO

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Genome-wide analysis of H3K79 dimethylation in normal and MLL-AF4 leukemic pre-B cells

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