H3K79 methylation profiles define murine and human MLL-AF4 leukemias
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ABSTRACT: We created a mouse model where conditional expression of physiologic levels of an Mll-AF4 fusion oncogene induces development of acute lymphoblastic (ALL) or acute myeloid leukemias (AML). Immunophenotypic and gene expression analysis of the ALL cells demonstrated bone marrow replacement with B-precursor cells which express a gene expression profile that has significant overlap with profiles in human MLL-rearranged ALL. This SuperSeries is composed of the SubSeries listed below.
ORGANISM(S): Mus musculus Homo sapiens
PROVIDER: GSE12363 | GEO | 2008/11/04
SECONDARY ACCESSION(S): PRJNA113189
REPOSITORIES: GEO
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