Transcriptomics

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Expression data from bone marrow of human subjects (3 essential thrombocythemia, 2 primary myelofibrosis, and 3 controls)


ABSTRACT: Fibrosis is the hallmark of primary myelofibrosis, a disease characterized by increased TGF-β bioavailability in bone marrow and spleen from both patients and mouse models. The aim of this study was to verify the role of TGF-β signaling in comparison to essential thrombocythemia and non-diseased control by using human bone marrow. We used RNA microarrays to investigate gene expression in bone marrow and identified distinct classes of up/down-regulated genes during this process.

ORGANISM(S): Homo sapiens

PROVIDER: GSE123732 | GEO | 2018/12/13

REPOSITORIES: GEO

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