Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Human Bacille Calmette-Guérin vaccination elicits trained immunity via the hematopoietic progenitor compartment [ATAC-seq]

ABSTRACT: Induction of trained immunity by human Bacille-Calmette-Guérin (BCG) vaccination is implicated in the beneficial heterologous effects of the vaccine, but the underlying mechanisms remain elusive. We performed global transcriptome analysis of sorted progenitors from bone marrow before (D0) and 90 days after vaccination (D90). BCG vaccination induced transcriptomic myeloid priming of the hematopoietic stem and progenitor cell (HSPC) compartment marked by the upregulation of myeloid and granulocytic pathways alongside the induction of transcription factors connected to myeloid cell function, namely Hepatocyte Nuclear Factors (HNF). These findings are corroborated by higher granulocyte numbers in BCG-vaccinated infants, HNF1-related SNP variants correlating with immune training and elevated serum levels of the HNF1 target gene SERPINA1. Taken together, we reveal a transcriptomic reprograming of HSPCs and peripheral monocytes as a trait of in vivo BCG-induced trained immunity.

ORGANISM(S): Homo sapiens

PROVIDER: GSE124219 | GEO | 2020/06/30

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Human Bacille Calmette-Guérin vaccination elicits trained immunity via the hematopoietic progenitor compartment [PBMC]

Project description:Induction of trained immunity by human Bacille-Calmette-Guérin (BCG) vaccination is implicated in the beneficial heterologous effects of the vaccine, but the underlying mechanisms remain elusive. We performed global transcriptome analysis of sorted progenitors from bone marrow before (D0) and 90 days after vaccination (D90). BCG vaccination induced transcriptomic myeloid priming of the hematopoietic stem and progenitor cell (HSPC) compartment marked by the upregulation of myeloid and granulocytic pathways alongside the induction of transcription factors connected to myeloid cell function, namely Hepatocyte Nuclear Factors (HNF). These findings are corroborated by higher granulocyte numbers in BCG-vaccinated infants, HNF1-related SNP variants correlating with immune training and elevated serum levels of the HNF1 target gene SERPINA1. Taken together, we reveal a transcriptomic reprograming of HSPCs and peripheral monocytes as a trait of in vivo BCG-induced trained immunity.

2020-06-30 | GSE124217 | GEO

Human Bacille Calmette-Guérin vaccination elicits trained immunity via the hematopoietic progenitor compartment [bone marrow]

2020-06-30 | GSE124218 | GEO

Comparison between immune cells from mice challenged with Bacille Calmette Guérin (BCG)

Project description:Microglia and macrophages are immune cells that differ in the inflammatory response to immune challenge. The purpose of this study was to profile mRNA levels (transcriptome) to better understand differences between immune cells 7 days after BCG challenge

2016-09-09 | GSE76069 | GEO

Human Bacille Calmette-Guérin vaccination elicits trained immunity via the hematopoietic progenitor compartment

Project description:Human Bacille Calmette-Guérin vaccination elicits trained immunity via the hematopoietic progenitor compartment

| PRJNA511000 | ENA

Transcriptomes of human neutrophils before and after in vivo exposure to Bacillus Calmette-Guérin vaccine

Project description:Innate immune memory is the phenomenon whereby innate immune cells undergo functional reprogramming after exposure to microbial components. In this study we apply epigenomic and transcriptomic analysis to circulating neutrophils from a clinical trial of BCG vaccination in healthy adults.

2020-09-30 | GSE153727 | GEO

Epigenome-Wide Association Study of Bacillus Calmette Guerin vaccination in human circulating monocytes

Project description:Trained immunity is a phenomenon whereby innate immune cells such as monocytes or macrophages undergo functional reprogramming after exposure to certain microbial components, altering their responses to future exposures. This study profiled genome-wide DNA methylation in purified human monocytes 15 months after BCG vaccination.

2022-08-02 | GSE168779 | GEO

H3K4me3 ChIP-seq of human neutrophils before and after in vivo exposure to Bacillus Calmette-Guérin vaccine

2020-09-30 | GSE153728 | GEO

Human Bacille Calmette-Guérin vaccination elicits trained immunity via the hematopoietic progenitor compartment [PBMC]

Project description:Human Bacille Calmette-Guérin vaccination elicits trained immunity via the hematopoietic progenitor compartment [PBMC]

| PRJNA511002 | ENA

Epigenomes and transcriptomes of human monocytes before and after in vivo exposure to Bacillus Calmette-Guérin vaccine

Project description:Innate immune memory is the phenomenon whereby innate immune cells such as monocytes or macrophages undergo functional reprogramming after exposure to microbial components. In this study, we apply epigenomic and transcriptomic analysis to a clinical trial of BCG vaccination in healthy adults.

2018-01-08 | GSE104149 | GEO

Human Bacille Calmette-Guérin vaccination elicits trained immunity via the hematopoietic progenitor compartment [bone marrow]

Project description:Human Bacille Calmette-Guérin vaccination elicits trained immunity via the hematopoietic progenitor compartment [bone marrow]

| PRJNA511004 | ENA