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Differential regulation of gene expression in neurons by spontaneous or sensory-driven activity and its dysregulation with aging

ABSTRACT: We identify a network of genes that change immediately after odor and light exposure in peripheral and central nervous system tissues in the model Drosophila melanogaster. We demonstrate in the antenna, that this regulation is dependent on olfactory signaling. This study provides several intriguing candidate genes that have potential for involvement in synaptic plasticity and learning and memory. We find that regulation of these genes is disrupted in ageing flies that are memory compromised. This provides a framework to both characterize this important class of genes and understand how their regulation contributes to the molecular mechanisms behind declining memory. Furthermore, many of our strongest candidates could prove to be valuable tools for neuronal circuit tracing in this amenable genetic model system.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE124343 | GEO | 2021/12/17

REPOSITORIES: GEO

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