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The cross-talk between TGF-b and periostin can be targeted for pulmonary fibrosis

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE124782 | GEO | 2019/09/17

REPOSITORIES: GEO

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The cross-talk between TGF-b and periostin can be targeted for pulmonary fibrosis [AR2857]

Project description:Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized as progressive and irreversible fibrosis in the interstitium of lung tissues. There is still an unmet need to develop a novel therapeutic drug for IPF. We have previously demonstrated that periostin, a matricellular protein, plays an important role in the pathogenesis of pulmonary fibrosis. However, the underlying mechanism of how periostin causes pulmonary fibrosis remains unclear. In this study, we sought to see whether the cross-talk between transforming growth factor-b (TGF-b), a central mediator in the pathogenesis of pulmonary fibrosis, and periostin in lung fibroblasts leads to generation of pulmonary fibrosis and whether taking advantage of the cross-talk between TGF-b and periostin, inhibitors for integrin aVb3, a periostin receptor, can block pulmonary fibrosis in the model mice. We found that there exists a cross-talk between TGF-b and periostin signals via aVb3/b5 converging into Smad3. This cross-talk is important for expression of several downstream molecules of TGF-b including serpin family E member 1, CCN family member 2/connective tissue growth factor, insulin-like growth factor binding protein-3, and IL-11, all of which have been already shown to be important for pulmonary fibrosis. We, moreover, found several potent integrin inhibitors to block the cross-talking with TGF-b signals and CP4715, one of the compounds, improved bleomycin-induced pulmonary fibrosis in mice. These results suggest that the cross-talk between TGF-b and periostin can be targeted for pulmonary fibrosis and that CP4715 can be a potential therapeutic agent to block the cross-talk between TGF-b and periostin.

2019-09-17 | GSE124781 | GEO

The cross-talk between TGF-b and periostin can be targeted for pulmonary fibrosis [AR2819]

2019-09-17 | GSE124780 | GEO

Cross-Talk between Transforming Growth Factor-β and Periostin Can Be Targeted for Pulmonary Fibrosis.

Project description:Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized as progressive and irreversible fibrosis in the interstitium of lung tissues. There is still an unmet need to develop a novel therapeutic drug for IPF. We have previously demonstrated that periostin, a matricellular protein, plays an important role in the pathogenesis of pulmonary fibrosis. However, the underlying mechanism of how periostin causes pulmonary fibrosis remains unclear. In this study, we sought to learn whether the cross-talk between TGF-β (transforming growth factor-β), a central mediator in pulmonary fibrosis, and periostin in lung fibroblasts leads to generation of pulmonary fibrosis and whether inhibitors for integrin αVβ3, a periostin receptor, can block pulmonary fibrosis in model mice and the TGF-β signals in fibroblasts from patients with IPF. We found that cross-talk exists between TGF-β and periostin signals via αVβ3/β5 converging into Smad3. This cross-talk is necessary for the expression of TGF-β downstream effector molecules important for pulmonary fibrosis. Moreover, we identified several potent integrin low-molecular-weight inhibitors capable of blocking cross-talk with TGF-β signaling. One of the compounds, CP4715, attenuated bleomycin-induced pulmonary fibrosis in vivo in mice and the TGF-β signals in vitro in fibroblasts from patients with IPF. These results suggest that the cross-talk between TGF-β and periostin can be targeted for pulmonary fibrosis and that CP4715 can be a potential therapeutic agent to block this cross-talk.

| S-EPMC6993541 | biostudies-literature

The cross-talk between TGF-b and periostin can be targeted for pulmonary fibrosis

Project description:The cross-talk between TGF-b and periostin can be targeted for pulmonary fibrosis

| PRJNA513470 | ENA

The cross-talk between TGF-b and periostin can be targeted for pulmonary fibrosis [AR2857]

Project description:The cross-talk between TGF-b and periostin can be targeted for pulmonary fibrosis [AR2857]

| PRJNA513471 | ENA

The cross-talk between TGF-b and periostin can be targeted for pulmonary fibrosis [AR2819]

Project description:The cross-talk between TGF-b and periostin can be targeted for pulmonary fibrosis [AR2819]

| PRJNA513472 | ENA

The cross talk occurring between bifidobacteria in the mammalian's gut microbiota

Project description:This SuperSeries is composed of the SubSeries listed below.

2017-08-23 | GSE65829 | GEO

Cross-talk between ovarian cancer cells and macrophages through periostin promotes macrophage recruitment.

Project description:Tumor-associated macrophages (TAMs) contribute to tumor progression, but it is not clear how they are recruited to tumor sites. Here we showed that periostin (POSTN) was present at high levels in ovarian cancer ascetic fluids and was correlated with CD163+ TAMs. The high POSTN level and macrophage infiltration were inversely associated with relapse-free survival for ovarian cancer patients. In vitro studies showed that coculture with macrophages significantly increased POSTN production in ovarian cancer cells. Further investigation found that POSTN production in ovarian cancer cells was promoted by transforming growth factor-? generated by macrophages. Moreover, siRNA of POSTN and POSTN neutralizing antibody treatment showed that ovarian cancer cell-derived POSTN promoted the recruitment of macrophages and modulated their cytokine secretion profile. Collectively, these data indicated that POSTN was an important factor for macrophage recruitment in the tumor microenvironment and is involved in the interactions between macrophages and ovarian cancer cells.

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Unexpected cross-talk between the pathogen defense mechanisms of apoptosis, necroptosis, and pyroptosis.

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-09-20 | GSE132134 | GEO

Cross-talk between ILC2 and Gata3high Treg locally constrains adaptive type 2 immunity

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-07-19 | GSE230599 | GEO