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Identifying genomic predictors of sensitivity to immune checkpoint therapy in mouse models of TNBC

ABSTRACT: We created new mouse mammary tumor models to identify biomarkers of sensitivity to immune checkpoint inhibitors. Using these models in a syngeneic transplant system and treating with anti-PD1/anti-CTLA4 combination therapy, we profiled treated and non-treated tumors by RNA-SEQ. Herein, the profiled tumors represent models that are resistant or senstitive to immune checkpoint inhibitors at distinct timepoints of therapy and tumor progression.

ORGANISM(S): Mus musculus

PROVIDER: GSE124821 | GEO | 2019/11/13

REPOSITORIES: GEO

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