Other

Dataset Information

0

PNET-seq (Pol II Ser5) in Arabidopsis


ABSTRACT: Intronic transposon elements (TEs) comprise a large proportion in eukaryotic genomes, but how they regulate the host genes remains to be explored. Our forward genetic screen disclosed the plant specific RNA polymerases IV and V in suppressing intronic TE-mediated cryptic transcription initiation of a chimeric transcripts at FLC (FLCTE). Initiation of FLCTE transcription is blocked by the locally formed intronic heterochromatin, and RNA Pol V direct associates and establishes intronic heterochromatin, thus inhibits the entry of RNA Pol II Ser5p and the occupancy of H3K4 methylation for promoting initiation. Genome-wide Pol II Ser5p native elongation transcription sequencing revealed that this is a common mechanism among intronic heterochromatin-containing genes. This study sheds light on deeply understanding the function of intronic heterochromatin on host genes expression in eukaryotic genome.

ORGANISM(S): Arabidopsis thaliana

PROVIDER: GSE125096 | GEO | 2019/11/01

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

| PRJNA515215 | ENA
2018-09-30 | GSE109974 | GEO
2018-09-30 | GSE117014 | GEO
2015-01-05 | E-GEOD-63314 | biostudies-arrayexpress
2021-02-04 | MSV000086806 | MassIVE
2018-10-06 | GSE106881 | GEO
2015-11-01 | E-GEOD-68203 | biostudies-arrayexpress
2012-06-04 | E-GEOD-37519 | biostudies-arrayexpress
2019-07-10 | GSE123980 | GEO
2024-05-31 | PXD037842 | Pride