Identification of genes are regulated by DROSHA at mRNA level [microarray]

ABSTRACT: Purpose: DROSHA plays an important role in breast cancer progression. Exploring the gene expression profiles regulated by DROSHA will facilitate to understand the mechanism which is responsible for DROSHA-induced breast cancer development. Results: We found that 105 genes were significantly up-regulated during DROSHA silencing in MDA-MB-231 cells, 200 genes were significantly down-regulated during DROSHA silencing in MDA-MB-231 cells. Conclusions: Our study indicated that DROSHA-mediated 305 differentially expressed genes might be invovled in breast cancer development.

ORGANISM(S): Homo sapiens

PROVIDER: GSE125705 | GEO | 2021/01/28

REPOSITORIES: GEO