Genomics

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Characterization of human erythroid chromatin in a two-phase liquid differentiation system


ABSTRACT: A two-phase liquid differentiation of peripheral blood mononuclear cells (PBMC) can be used to study human erythroid cells. To determine the epigenetic landscape of erythroid cells derived from PBMC we have performs ChIP-seq for histone marks associated with promoters (H3K4me3), enhancers (H3K4me1) and polycomb repression (H3K27me3) as well as for chromatin bound pol2. In addition we characterized the binding of the boundary element CTCF and key erythroid transcription factors NF-E2 and SCL/TAL.

ORGANISM(S): Homo sapiens

PROVIDER: GSE125753 | GEO | 2020/06/29

REPOSITORIES: GEO

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