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Transcription profiling of IL-4-expressing CD4 T cells in the lung and lung-draining lymph nodes

ABSTRACT: Using single cell RNA-sequencing and whole-genome targeted transcription profiling, this study reveals that helminth infection causes the expansion of distinct but clonally related IL-4-competent CD4+ T cells in the lung and lung-draining lymphoid tissues providing insight into tissue-specific mechanisms of type-2 cytokine regulation and the lineage commitment of T-helper 2 (Th2) and T follicular helper (Tfh) cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE125788 | GEO | 2021/05/17

REPOSITORIES: GEO

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