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Gene expression signatures for murine B cells from tumor-draining lymph nodes

ABSTRACT: To determine the influence of primary tumors on pre-metastatic lymph nodes, we have employed whole genome microarray expression profiling as a discovery platform to identify gene signatures of B cells from tumor-draining lymph nodes, compared with normal lymph nodes. We subcutaneously inoculated C57BL/6 mice with the 4T1 mammary carcinoma. Two weeks later, tumor-draining lymph nodes were dissociated and B cells (CD19+) were sorted. Lymph nodes B cells from normal mice without tumor bearing were set as controls.

ORGANISM(S): Mus musculus

PROVIDER: GSE113250 | GEO | 2018/04/18

REPOSITORIES: GEO

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