Transcriptomics

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Hypoxia Triggers the Intravasation of Clustered Circulating Tumor Cells


ABSTRACT: Circulating tumor cells (CTCs) are shed from solid cancers in the form of single or clustered cells, with the latter displaying an extraordinary ability to initiate metastasis. Yet, the biological phenomena that trigger the intravasation of CTC clusters are largely unknown. Here, we compare gene expression of hypoxic and normoxic CTC clusters to identify genes that are not only upregulated as a consequence to hypoxia, but that may also play a pivotal role in promoting CTC clusters generation and metastasis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE126669 | GEO | 2020/09/08

REPOSITORIES: GEO

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