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LKB1 orchestrates dendritic cell metabolic quiescence and anti-tumor immunity [MoGene-2_0-st]

ABSTRACT: Loss of LKB1 leads to aberrant DC maturation and production of cytokines and immunoregulatory molecules. DCs (n = 7 per genotype) were isolated from the spleen, and CD25+CD4+ Tregs (n = 4 for WT, n = 3 for LKB1ΔDC mice) were isolated from the spleen and peripheral lymph nodes of WT and LKB1ΔDC mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE128473 | GEO | 2019/04/16

REPOSITORIES: GEO

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LKB1 orchestrates dendritic cell metabolic quiescence and anti-tumor immunity [HT_MG-430_PM]

Project description:Loss of LKB1 leads to aberrant DC maturation and production of cytokines and immunoregulatory molecules. DCs (n = 7 per genotype) were isolated from the spleen, and CD25+CD4+ Tregs (n = 4 for WT, n = 3 for LKB1ΔDC mice) were isolated from the spleen and peripheral lymph nodes of WT and LKB1ΔDC mice.

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LKB1 orchestrates dendritic cell metabolic quiescence and anti-tumor immunity [MoGene-2_0-st]

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Project description:The goals of this study was to compare hepatic transcriptome profiling (RNA-seq) in wild type (WT) and Liver Kinase B1 knock out (LKB1 KO) mice Methods: hepatocyte mRNA profiles of 10-weeks-old WT and LKB1 KO mice were generated, in triplicate, using Illumina NextSeq technology. The sequence reads that passed quality filters were analyzed at the gene level.

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