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Identification of renal resident macrophages across species [10X]

ABSTRACT: We use single cell RNA sequencing to identify an evolutionarily conserved gene expression signature in resident macrophages. Based on our single cell data, we show the presence of a core gene expression signature in a cluster of innate immune cells in mouse, rat, pig, and human kidney tissue. Further, using this gene expression signature, we identify novel candidate markers for resident macrophages that span all 4 species tested.

ORGANISM(S): Mus musculus Rattus norvegicus Sus scrofa Homo sapiens

PROVIDER: GSE128992 | GEO | 2019/04/05

REPOSITORIES: GEO

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Identification of renal resident macrophages across species [C1]

Project description:We use single cell RNA sequencing to identify an evolutionarily conserved gene expression signature in resident macrophages. Based on our single cell data, we show the presence of a core gene expression signature in a cluster of innate immune cells in mouse, rat, pig, and human kidney tissue. Further, using this gene expression signature, we identify novel candidate markers for resident macrophages that span all 4 species tested.

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