Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single cell RNA-Seq of Ewing Sarcoma PDX data (PDX_Chromium)

ABSTRACT: We report the application of single-molecule-based sequencing technology for high-throughput profiling of 5 Ewing Sarcoma PDX (PDX-184, 352, 856, 861 and 1058) with the 10X Genomics Chromium technology.

ORGANISM(S): Homo sapiens

PROVIDER: GSE130024 | GEO | 2020/02/14

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Single cell RNA-Seq of Ewing Sarcoma PDX data (PDX_C1)

Project description:We report the application of single-molecule-based sequencing technology for high-throughput profiling of 3 Ewing Sarcoma PDX (PDX-83, 84 and 111) with the Fluidigm C1 technology.

2020-02-14 | GSE130023 | GEO

Single cell RNA-Seq of Ewing Sarcoma PDX data (PDX_Chromium)

Project description:Single cell RNA-Seq of Ewing Sarcoma PDX data (PDX_Chromium)

| PRJNA533607 | ENA

Single cell RNA-Seq of Ewing Sarcoma PDX data (PDX_C1)

Project description:Single cell RNA-Seq of Ewing Sarcoma PDX data (PDX_C1)

| PRJNA533608 | ENA

Single cell RNA-Seq from bone marrow Ewing patients

Project description:We report the application of single-molecule-based sequencing technology for high-throughput profiling of bone marrow Ewing patients

2020-02-14 | GSE130020 | GEO

Characteristics PDX

Project description:Characteristics PDX

| PRJEB74764 | ENA

Novel targeting of DNA methyltransferase activity inhibits Ewing sarcoma cell proliferation and enhances tumor cell sensitivity to DNA damaging drugs by activating the DNA damage response

Project description:Genome wide epigenomic analysis of Ewing Sarcoma human cell lines treated with 5AzadC and MC3343. Samples included 9 x TC-71, 9 x A673 samples, and 8 x PDX samples. For each cell line and condition ( 5AzadC, MC3343, Contol), we created 3 replicates, except PDX with 5AzadC treatment for which only 2 samples were created.

2022-06-01 | GSE202143 | GEO

Gene Expression data from Pdx-1CreAPC+/LP53L/L pancreatic ductal adenocarcinoma (PDAC) cells versus Pdx-1CreP53L/L normal pancreatic ductal cells

Project description:Analysis of primary PDAC cells established from Pdx-1CreAPCL/+p53L/L and Pdx-1Crep53L/L mice. APC haploinsufficiency combined with P53 loss in the pancreas drives MCN progression in mice. Results provide insight into molecular mechanisms invloved in the MCN formation of Pdx-1Cre APCL/+P53L/L mice. Pdx-1CreAPC+/LP53L/L PDAC cell lines and 2 Pdx-1CreP53L/L ductal cell lines were analyzed.

2014-10-01 | E-GEOD-61894 | biostudies-arrayexpress

PRC2 in Ewing tumors

Project description:We found the PRC2 component EZH2 to be upregulated by the pathognomonic fusion oncogene EWS-FLI1 in Ewing tumors and mesenchymal stem cells (Richter GH et al., Proc Natl Acad Sci U S A. 2009;106:5324-9). Downregulation of EZH2 by RNA interference in Ewing tumor cell lines suppressed oncogenic transformation in vitro and in vivo. These data suggest that EZH2 might play a central role in Ewing Tumor pathology. RNA from tumor samples was isolated with Trizol and subjected to microarray analysis using HG_U133A microarrays following the Affymetrix protocol. Ewing tumors vs. neuroblastoma controls

2009-04-29 | E-GEOD-15757 | biostudies-arrayexpress

Transcription profiling of human Ewing sarcoma samples and EWS-FLI-1 inhibited Ewing sarcoma cell lines

Project description:The cellular origin of Ewing tumor (ET), a tumor of bone or soft tissues characterized by specific fusions between EWS and ETS genes, is highly debated. Through gene expression analysis comparing ETs with a variety of normal tissues, we show that the profiles of different EWS-FLI1-silenced Ewing cell lines converge toward that of mesenchymal stem cells (MSC). Moreover, upon EWS-FLI1 silencing, two different Ewing cell lines can differentiate along the adipogenic lineage when incubated in appropriate differentiation cocktails. In addition, Ewing cells can also differentiate along the osteogenic lineage upon long-term inhibition of EWS-FLI1. These in silico and experimental data strongly suggest that the inhibition of EWS-FLI1 may allow Ewing cells to recover the phenotype of their MSC progenitor. Experiment Overall Design: Ewing tumors and EWS-FLI-1 inhibited cell lines were profiled on Affymetrix U133A (GPL96) arrays.

2008-06-15 | E-GEOD-7007 | biostudies-arrayexpress

Ewing samples and EWS-FLI-1 inhibited Ewing cell lines

2007-02-14 | GSE7007 | GEO