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POSH2 Promotes Breast Cancer Stem-Like Properties through JNK Activation and PTX3 Upregulation [PTX3_OE]

ABSTRACT: We conduct transcriptome comparison of control and PTX3-overexpressed HMLER cells to gain genomic insights on the biological processes that PTX3 is involved in breast cancer cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE130572 | GEO | 2020/03/16

REPOSITORIES: GEO

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POSH2 Promotes Breast Cancer Stem-Like Properties through JNK Activation and PTX3 Upregulation [HMLER_sublines]

Project description:We conduct transcriptome comparison of HMLER-derived CD44H,CD44LS and CD44L subpopulation cells to gain transcriptomic insights on the differences between breast cancer stem cells and non-breast cancer stem cells.

2020-03-16 | GSE130575 | GEO

POSH2 Promotes Breast Cancer Stem-Like Properties through JNK Activation and PTX3 Upregulation [MCF10AT_POSH2_OE]

Project description:We conduct transcriptome comparison of control and POSH2-overexpressed MCF10AT cells to gain genomic insights on the biological processes that POSH2 is involved in breast cancer cells.

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SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation.

Project description:Cancer stem-like cells (CSCs) are the tumorigenic cell subpopulation and contribute to cancer recurrence and metastasis. However, the understanding of CSC regulatory mechanisms remains incomplete. By transcriptomic analysis, we identify a scaffold protein SH3RF3 (also named POSH2) that is upregulated in CSCs of breast cancer clinical tumors and cancer cell lines, and enhances the CSC properties of breast cancer cells. Mechanically, SH3RF3 interacts with the c-Jun N-terminal kinase (JNK) in a JNK-interacting protein (JIP)-dependent manner, leading to enhanced phosphorylation of JNK and activation of the JNK-JUN pathway. Further the JNK-JUN signaling expands CSC subpopulation by transcriptionally activating the expression of Pentraxin 3 (PTX3). The functional role of SH3RF3 in CSCs is validated with patient-derived organoid culture, and supported by clinical cohort analyses. In conclusion, our work elucidates the role and molecular mechanism of SH3RF3 in CSCs of breast cancer, and might provide opportunities for CSC-targeting therapy.

| S-EPMC7237486 | biostudies-literature

POSH2 Promotes Breast Cancer Stem-Like Properties through JNK Activation and PTX3 Upregulation

Project description:POSH2 Promotes Breast Cancer Stem-Like Properties through JNK Activation and PTX3 Upregulation

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POSH2 Promotes Breast Cancer Stem-Like Properties through JNK Activation and PTX3 Upregulation [PTX3_OE]

Project description:POSH2 Promotes Breast Cancer Stem-Like Properties through JNK Activation and PTX3 Upregulation [PTX3_OE]

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POSH2 Promotes Breast Cancer Stem-Like Properties through JNK Activation and PTX3 Upregulation [HMLER_sublines]

Project description:POSH2 Promotes Breast Cancer Stem-Like Properties through JNK Activation and PTX3 Upregulation [HMLER_sublines]

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POSH2 Promotes Breast Cancer Stem-Like Properties through JNK Activation and PTX3 Upregulation [MCF10AT_POSH2_OE]

Project description:POSH2 Promotes Breast Cancer Stem-Like Properties through JNK Activation and PTX3 Upregulation [MCF10AT_POSH2_OE]

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POSH2 Promotes Breast Cancer Stem-Like Properties through JNK Activation and PTX3 Upregulation

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-03-16 | GSE130577 | GEO

Differenatiation of mRNA expression in PTX3-depleted macrophages

Project description:PTX3, as the long member of the pentraxin family, is produced mainly by dendritic cells, macrophages, and endothelial cells in response to inflammation. Growing amount of studies suggest that PTX3 can exert potential contradictory roles in inflammation regulation, antimicrobial resistance, and disease pathogenesis, depending on the tissue context, cellular source, and levels of production. To characterize the potential involvement of PTX3 in macrophage function, transcriptome sequencing (RNA-seq) was performed in human THP1-derived macrophages with PTX3 depletion. Notably,genes enrichment in PI3K/AKT signaling , JAK/STAT signaling and autophagy pathway were observed in PTX3 deficiency macrophages. This study highlights the critical roles of PTX3 on regulation macrophages homeostasis.

2023-10-01 | GSE192726 | GEO

Effect of PTX3 on gene expression of THP-1 macrophages

Project description:We aimed to investigate the effect of PTX3 on macrophages functions. After PTX3 stimulation for 18 h in THP-1 macrophages, total RNA were harvested for RNA-seq analysis of ctrl (n = 1) and PTX3 group (n = 1).

2023-03-20 | GSE227402 | GEO

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