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POSH2 Promotes Breast Cancer Stem-Like Properties through JNK Activation and PTX3 Upregulation [MCF10AT_POSH2_OE]

ABSTRACT: We conduct transcriptome comparison of control and POSH2-overexpressed MCF10AT cells to gain genomic insights on the biological processes that POSH2 is involved in breast cancer cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE130576 | GEO | 2020/03/16

REPOSITORIES: GEO

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POSH2 Promotes Breast Cancer Stem-Like Properties through JNK Activation and PTX3 Upregulation [PTX3_OE]

Project description:We conduct transcriptome comparison of control and PTX3-overexpressed HMLER cells to gain genomic insights on the biological processes that PTX3 is involved in breast cancer cells.

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POSH2 Promotes Breast Cancer Stem-Like Properties through JNK Activation and PTX3 Upregulation [HMLER_sublines]

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POSH2 Promotes Breast Cancer Stem-Like Properties through JNK Activation and PTX3 Upregulation

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-03-16 | GSE130577 | GEO

SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation.

Project description:Cancer stem-like cells (CSCs) are the tumorigenic cell subpopulation and contribute to cancer recurrence and metastasis. However, the understanding of CSC regulatory mechanisms remains incomplete. By transcriptomic analysis, we identify a scaffold protein SH3RF3 (also named POSH2) that is upregulated in CSCs of breast cancer clinical tumors and cancer cell lines, and enhances the CSC properties of breast cancer cells. Mechanically, SH3RF3 interacts with the c-Jun N-terminal kinase (JNK) in a JNK-interacting protein (JIP)-dependent manner, leading to enhanced phosphorylation of JNK and activation of the JNK-JUN pathway. Further the JNK-JUN signaling expands CSC subpopulation by transcriptionally activating the expression of Pentraxin 3 (PTX3). The functional role of SH3RF3 in CSCs is validated with patient-derived organoid culture, and supported by clinical cohort analyses. In conclusion, our work elucidates the role and molecular mechanism of SH3RF3 in CSCs of breast cancer, and might provide opportunities for CSC-targeting therapy.

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POSH2 Promotes Breast Cancer Stem-Like Properties through JNK Activation and PTX3 Upregulation

Project description:POSH2 Promotes Breast Cancer Stem-Like Properties through JNK Activation and PTX3 Upregulation

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POSH2 Promotes Breast Cancer Stem-Like Properties through JNK Activation and PTX3 Upregulation [PTX3_OE]

Project description:POSH2 Promotes Breast Cancer Stem-Like Properties through JNK Activation and PTX3 Upregulation [PTX3_OE]

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POSH2 Promotes Breast Cancer Stem-Like Properties through JNK Activation and PTX3 Upregulation [MCF10AT_POSH2_OE]

Project description:POSH2 Promotes Breast Cancer Stem-Like Properties through JNK Activation and PTX3 Upregulation [MCF10AT_POSH2_OE]

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POSH2 Promotes Breast Cancer Stem-Like Properties through JNK Activation and PTX3 Upregulation [HMLER_sublines]

Project description:POSH2 Promotes Breast Cancer Stem-Like Properties through JNK Activation and PTX3 Upregulation [HMLER_sublines]

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Hydrogen peroxide promotes Abeta production through JNK-dependent activation of gamma-secretase.

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