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SOX7 regulates MAPK/ERK-BIM mediated apoptosis in cancer cells

ABSTRACT: Here we showed that SOX7 was significantly downregulated in different cancer types, especially in lung and breast cancers. Low expression of SOX7 was associated with advanced stage of cancer with shorter overall survival. Cancer cells with loss of SOX7 promoted cell survival and colony formation, suppressed cellular apoptosis and produced a drug resistant phenotype against a variety of chemo/targeting therapeutic agents. Mechanistically, SOX7 induced cellular apoptosis through upregulation of genes associated with both P38 and apoptotic signaling pathway, as well as preventing the proteasome mediated degradation of pro-apoptotic protein BIM. Treatment of either a proteasome inhibitor MG132 or bortezomib, or with a p-ERK/MEK inhibitor U0126 attenuate the SOX7 promoted BIM degradation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE130917 | GEO | 2022/05/08

REPOSITORIES: GEO

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SOX7 regulates MAPK/ERK-BIM mediated apoptosis in cancer cells

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