Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Liver
SUBMITTER: Florian Stengel
LAB HEAD: Florian Stengel
PROVIDER: PXD045034 | Pride | 2024-09-24
REPOSITORIES: Pride
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202308_APAP_IsolationList_SIM_PRM.csv | Csv | |||
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F2307_jansenja_335.raw | Raw | |||
F2307_jansenja_341.raw | Raw | |||
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Cell death and differentiation 20231124 1
Paracetamol (acetaminophen, APAP) overdose severely damages mitochondria and triggers several apoptotic processes in hepatocytes, but the final outcome is fulminant necrotic cell death, resulting in acute liver failure and mortality. Here, we studied this switch of cell death modes and demonstrate a non-canonical role of the apoptosis-regulating BCL-2 homolog BIM/Bcl2l11 in promoting necrosis by regulating cellular bioenergetics. BIM deficiency enhanced total ATP production and shifted the bioen ...[more]