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Stationary phase gene regulation in M1 GAS by the group A Streptococcus protein RocA

ABSTRACT: We used RNA-Seq to assess how RocA regulates gene expression in stationary phase cultures of serotype M1 GAS

ORGANISM(S): Streptococcus pyogenes

PROVIDER: GSE131235 | GEO | 2019/11/22

REPOSITORIES: GEO

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Stationary phase gene regulation by the group A Streptococcus protein RocA

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Stationary phase gene regulation in M1 GAS by the group A Streptococcus protein RocA

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Project description:We sequenced mRNA transcripts from three isogenic M3 serotype GAS strains, parental (MGAS10870), complement (10870::rocAM1), and deletion (10870ΔrocA). There were no significant changes between the parental and revertant strain. Comparison of the parental and complemented strain revealed several virulence factors were up-regulated in the parental strain where RocA function was diminished. We concluded that RocA, through direct or indirect mechanisms, is able to control numerous virulence genes and this lack of RocA regulation increases expression of virulence factors, which contributes to the hyper-virulent state of serotype M3 GAS.

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