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A composite immune signature parallels disease progression across T1D subjects (Affymetrix Cohort 2)

ABSTRACT: We used an array-based bioassay whereby serum is used to induce transcription in healthy “reporter” leukocytes. Serum samples were obtained from control-arm subjects enrolled in 3 clinical trials evaluating immunotherapies in T1D that were conducted by the Immune Tolerance Network. The included trials evaluated immune-modifying therapy in new-onset T1D, with similar trial timecourses, primary outcomes, and data and sample collection. Total RNA was isolated from the reporter cell line for gene expression analysis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE131524 | GEO | 2020/02/03

REPOSITORIES: GEO

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