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A composite immune signature parallels disease progression across T1D subjects (Affymetrix Cohort 2)

ABSTRACT: A composite immune signature parallels disease progression across T1D subjects (Affymetrix Cohort 2)

PROVIDER: PRJNA543895 | ENA |

REPOSITORIES: ENA

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A composite immune signature parallels disease progression across T1D subjects (Affymetrix Cohort 0)

Project description:A composite immune signature parallels disease progression across T1D subjects (Affymetrix Cohort 0)

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A composite immune signature parallels disease progression across T1D subjects

Project description:A composite immune signature parallels disease progression across T1D subjects

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A composite immune signature parallels disease progression across T1D subjects (Affymetrix Cohort 2)

Project description:We used an array-based bioassay whereby serum is used to induce transcription in healthy “reporter” leukocytes. Serum samples were obtained from control-arm subjects enrolled in 3 clinical trials evaluating immunotherapies in T1D that were conducted by the Immune Tolerance Network. The included trials evaluated immune-modifying therapy in new-onset T1D, with similar trial timecourses, primary outcomes, and data and sample collection. Total RNA was isolated from the reporter cell line for gene expression analysis.

2020-02-03 | GSE131524 | GEO

A composite immune signature parallels disease progression across T1D subjects (Affymetrix Cohort 0)

Project description:Technical replicate testing was performed to determine the measurement precision of each analyte in the array-based bioassay. Serum from subjects (n=5) with T1D was used to induce transcription in healthy “reporter” leukocytes. Three independent serum aliquots per subject were thawed and used to stimulate separate wells of reporter cells. Total RNA was isolated from the reporter cell line for gene expression analysis.

2020-02-03 | GSE131523 | GEO

A composite immune signature parallels disease progression across T1D subjects (RNA-Seq Cohort 0 WB)

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A composite immune signature parallels disease progression across T1D subjects (RNA-Seq Cohort 2 Cell Sorted)

Project description:A composite immune signature parallels disease progression across T1D subjects (RNA-Seq Cohort 2 Cell Sorted)

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A composite immune signature parallels disease progression across T1D subjects (RNA-Seq Cohort 0 Cell Sorted)

Project description:A composite immune signature parallels disease progression across T1D subjects (RNA-Seq Cohort 0 Cell Sorted)

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A composite immune signature parallels disease progression across T1D subjects (RNA-Seq Cohort 2 Cell Sorted)

Project description:Peripheral blood mononuculear cells were thawed and sorted into B cell, CD4+ T cells, CD8+ T cells, and monocytes. Samples were obtained from control-arm subjects enrolled in 2 clinical trials evaluating immunotherapies in T1D that were conducted by the Immune Tolerance Network. The trials had similar study timepoints, clinical and metabolic measurements, and data and sample collection plans. Total RNA was isolated from the sorted cell populations and then RNAseq libraries were prepared.

2020-02-03 | GSE131527 | GEO

A composite immune signature parallels disease progression across T1D subjects (RNA-Seq Cohort 0 Cell Sorted)

Project description:Technical replicate testing was performed to determine the measurement precision of each analyte. Peripheral blood mononuculear cells were processed and frozen down from blood samples collected from healthy control subjects (n=3) or subjects with Systemic Lupus Erythematosus (n=3). Three separate PBMC aliquots per subject were then independently thawed and sorted by flow into B cell, CD4+ T cell, CD8+ T cell, and monocyte populations. Total RNA was isolated from the sorted cell populations and then RNAseq libraries were prepared.

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A composite immune signature parallels disease progression across T1D subjects (RNA-Seq Cohort 0 WB)

Project description:Technical replicate testing was performed to determine the measurement precision of each analyte. Peripheral blood samples were collected in tempus tubes from a healthy control subject with no family history of autoimmunity (n=1) and from subjects with Type 1 diabetes (n=4). Total RNA was isolated independently from 3 replicate aliquots of the same tempus samples and then globin-reduced. RNAseq libraries were prepared from the globin-reduced RNA.

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