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In vivo endothelial transcriptomic responses to diesel engine exhaust are potentiated by hypercholesterolemia

ABSTRACT: By means of Operon V3 microarrrays, the in vivo, aortic endothelial transcriptomic responses to chronic (30 day) whole body exposure to diesel exhaust were assessed in wild type and Apo E (-/-) mice. The in vitro response of cultured Svec 4-10 cells exposed to a soluble extract extract of diesel engine particulate were similarly assessed.

ORGANISM(S): Mus musculus

PROVIDER: GSE13160 | GEO | 2008/12/15

SECONDARY ACCESSION(S): PRJNA109743

REPOSITORIES: GEO

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Transcriptomic Changes in the Nasal Epithelium Associated with Diesel Engine Exhaust Exposure

Project description:Diesel engine exhaust (DEE) is one of the major contributors to air pollution around the world, and exposure to DEE is associated with lung cancer and other airway diseases. Although recent studies have investigated the effects of exposure to DEE, the mechanisms by which it leads to lung cancer pathogenesis are not well understood. We have previously investigated the transcriptomic changes that occur due to exposure to cigarette smoke and burning of bituminous (smoky) as well as anthracite (smokeless) coal in the airway epithelium, and in this study we assess the gene expression alterations in the nasal epithelium that are associated with chronic DEE exposure of diesel engine factory workers to better understand which molecular changes may lead to pathogenesis of lung cancer.

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Transcriptomic Changes in the Nasal Epithelium Associated with Diesel Engine Exhaust Exposure

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Hypercholesterolemia potentiates aortic endothelial response to inhaled diesel exhaust.

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