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Effect of the noncoding RNA produced by ZIKA virus (ZIKV) on expression of Aedes aegypti genes

ABSTRACT: We report that ZIKV noncoding RNA (sfRNA) affect expression of mosquito genes upon ZIKV infection. We constructed sfRNA-deficient ZIKV mutant (xrRNA2') and conducted transcriptome-wide gene expression profiling of mosquitos infected with WT and xrRNA2' viruses. We found that sfRNA inhibits apoptosis in the infected tissues of Ae. aegypti by altering expression of mosquito genes that control cell death and survival.

ORGANISM(S): Aedes aegypti

PROVIDER: GSE131827 | GEO | 2020/03/24

REPOSITORIES: GEO

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