Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The Single Cell Transcriptomic Landscape of Early Human Diabetic Nephropathy

ABSTRACT: We report the early transcriptional changes in human diabetic nephropathy by single nucleus RNA sequencing

ORGANISM(S): Homo sapiens

PROVIDER: GSE131882 | GEO | 2019/09/10

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

The Single Cell Transcriptomic Landscape of Early Human Diabetic Nephropathy

Project description:The Single Cell Transcriptomic Landscape of Early Human Diabetic Nephropathy

| PRJNA545232 | ENA

Diabetic nephropathy

Project description:Gene expression profiling in glomeruli from human kidneys with diabetic nephropathy Keywords = Diabetes Keywords = kidney Keywords = glomeruli Keywords: other

2004-04-01 | GSE1009 | GEO

The single-cell transcriptomic landscape of early human diabetic nephropathy.

Project description:Diabetic nephropathy is characterized by damage to both the glomerulus and tubulointerstitium, but relatively little is known about accompanying cell-specific changes in gene expression. We performed unbiased single-nucleus RNA sequencing (snRNA-seq) on cryopreserved human diabetic kidney samples to generate 23,980 single-nucleus transcriptomes from 3 control and 3 early diabetic nephropathy samples. All major cell types of the kidney were represented in the final dataset. Side-by-side comparison demonstrated cell-type-specific changes in gene expression that are important for ion transport, angiogenesis, and immune cell activation. In particular, we show that the diabetic thick ascending limb, late distal convoluted tubule, and principal cells all adopt a gene expression signature consistent with increased potassium secretion, including alterations in Na+/K+-ATPase, WNK1, mineralocorticoid receptor, and NEDD4L expression, as well as decreased paracellular calcium and magnesium reabsorption. We also identify strong angiogenic signatures in glomerular cell types, proximal convoluted tubule, distal convoluted tubule, and principal cells. Taken together, these results suggest that increased potassium secretion and angiogenic signaling represent early kidney responses in human diabetic nephropathy.

| S-EPMC6765272 | biostudies-literature

Human PBMCs: Healthy vs Diabetic nephropathy vs ESRD

Project description:Transcriptional profiling of human PBMCs comparing healthy controls, patients with diabetic nephropathy and patients with ESRD. PBMCs were analyzed as they mediate inflammatory injury. Goal was to determine effects of increasing severity of diabetic nephropathy on global PBMC gene expression. Microarray analysis of PBMCs taken from patients with varying degrees of diabetic nephropathy.

2020-12-01 | GSE142153 | GEO

diabetic nephropathy streptozotocin db db

Project description:diabetes, mouse models, diabetic nephropathy, streptozotocin db/db Keywords: other

2004-01-20 | GSE710 | GEO

Cellular and Molecular Linkage between Diabetic Nephropathy and Diabetic Retinopathy

Project description:Diabetic nephropathy and diabetic retinopathy are related. We used scRNA-seq and RNA-seq to analyze the cellular linkage between them.

2023-08-15 | GSE204880 | GEO

Single-cell RNAseq analysis of renal endothelial cells in murine diabetic nephropathy

Project description:We applied scRNAseq analysis to investigate the renal endothelial compartments in the murine diabetic nephropathy

2024-05-01 | GSE192687 | GEO

RNA Expression data for early diabetic nephropathy (EDN)

Project description:There is a temporal window from the time diabetes is diagnosed to the appearance of overt kidney disease during which time the disease progresses quietly without detection. Currently, there is no way to detect early diabetic nephropathy (EDN). Here we performed an unbiased assessment of gene-expression analysis of postmortem human kidneys using microarrays to identify candidate genes that may contribute to EDN.

2018-07-03 | GSE111154 | GEO

gut microbiome in diabetic nephropathy

Project description:gut microbiome in diabetic nephropathy

| PRJEB36826 | ENA

LncRNAs expression profiles in renal tissues from patients with diabetic nephropathy

Project description:In order to more accurately and objectively clarify the biological role of lncRNAs in diabetic nephropathy, we detected their expression profiles in renal tissues from patients with diabetic nephropathy.

2022-11-24 | GSE218344 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data