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The RNA exosome nuclease complex regulates human embryonic stem cell differentiation [HITS-CLIP]

ABSTRACT: This work shows that the exosome modulates the levels of LINE-1 retrotransposons, miRNAs, lncRNAs and specific mRNAs that encode developmental regulators or affect their expression. The exosome restrains differentiation in part by degrading transcripts encoding FOXH1, a transcription factor crucial for mesendoderm formation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE132360 | GEO | 2019/07/11

REPOSITORIES: GEO

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