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Genome-wide screen unveils the synthetic lethality targets of mitomycin C

ABSTRACT: To dig out the synthetic lethality targets of mitomycin C, we we performed Genome-scale CRISPR-Cas9 knockout screening in SNU-1 with 0.1% DMSO or 0.3 µM MMC for 14 days. We found that BRCA2 is a synthetic lethality target of mitomycin C.

ORGANISM(S): Homo sapiens

PROVIDER: GSE132431 | GEO | 2022/06/08

REPOSITORIES: GEO

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