Estrogen response in breast cancer cell line MCF-7 is dependent on NR2F2 [RNA-seq]
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ABSTRACT: We show that most binding events of NR2F2 occur together with the ERα binding sites.To address the functional relationship between NR2F2 and ERα, we assessed the role of NR2F2 in oestrogen-induced growth in ER positive cell line MCF-7. The MTT experiment showed that inhibition of NR2F2 prevented the oestrogen-induced proliferation of MCF-7 cells.To further explore the effect of NR2F2 on estrogen response, We expanded our knockdown studies by performing RNA-seq analysis for MCF-7 cells transfected with control or NR2F2 shRNAs with or without E2.
ORGANISM(S): Homo sapiens
PROVIDER: GSE132433 | GEO | 2019/10/15
REPOSITORIES: GEO
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