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Male mice brain transcriptome in Bahd1 +/+ and Bahd1 -/- at adult and E16.5 embryo stages

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE132580 | GEO | 2020/05/21

REPOSITORIES: GEO

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Male mice brain transcriptome in Bahd1 +/+ and Bahd1 -/- at adult and E16.5 embryo stages

Project description:Male mice brain transcriptome in Bahd1 +/+ and Bahd1 -/- at adult and E16.5 embryo stages

| PRJNA548389 | ENA

BAHD1 haploinsufficiency results in anxiety-like phenotypes in male mice.

Project description:BAHD1 is a heterochomatinization factor recently described as a component of a multiprotein complex associated with histone deacetylases HDAC1/2. The physiological and patho-physiological functions of BAHD1 are not yet well characterized. Here, we examined the consequences of BAHD1 deficiency in the brains of male mice. While Bahd1 knockout mice had no detectable defects in brain anatomy, RNA sequencing profiling revealed about 2500 deregulated genes in Bahd1-/- brains compared to Bahd1+/+ brains. A majority of these genes were involved in nervous system development and function, behavior, metabolism and immunity. Exploration of the Allen Brain Atlas and Dropviz databases, assessing gene expression in the brain, revealed that expression of the Bahd1 gene was limited to a few territories and cell subtypes, particularly in the hippocampal formation, the isocortex and the olfactory regions. The effect of partial BAHD1 deficiency on behavior was then evaluated on Bahd1 heterozygous male mice, which have no lethal or metabolic phenotypes. Bahd1+/- mice showed anxiety-like behavior and reduced prepulse inhibition (PPI) of the startle response. Altogether, these results suggest that BAHD1 plays a role in chromatin-dependent gene regulation in a subset of brain cells and support recent evidence linking genetic alteration of BAHD1 to psychiatric disorders in a human patient.

| S-EPMC7224496 | biostudies-literature

Transcriptome analysis of whole brain tissue from Bahd1+/+ (WT) and Bahd1-/- (KO) mouse embryos (stage E16.5)

Project description:Comparisons of brain gene expression profiles of Bahd1-KO mouse embryos to those of wild-type littermates

2020-05-21 | GSE132579 | GEO

Transcriptome expression profile of tissue from BAHD1+/+ (WT) and BAHD1-/- (KO) mice

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-03-15 | E-GEOD-53443 | biostudies-arrayexpress

Transcriptome expression profile of tissue from BAHD1+/+ (WT) and BAHD1-/- (KO) mice

Project description:This SuperSeries is composed of the SubSeries listed below.

2016-03-15 | GSE53443 | GEO

Transcriptome expression profile of embryonic liver and placenta tissue from BAHD1+/+ (WT) and BAHD1-/- (KO) mice at embryonic day E16.5

Project description:Comparisons of embryonic liver and placenta gene expression profiles of BAHD1-KO mice to those of wild-type littermate mice

2016-03-15 | GSE53442 | GEO

Transcriptome expression profile of embryonic liver and placenta tissue from BAHD1+/+ (WT) and BAHD1-/- (KO) mice at embryonic day E16.5

Project description:Comparisons of embryonic liver and placenta gene expression profiles of BAHD1-KO mice to those of wild-type littermate mice We used DNA microarrays to identify the repertoire of genes differentially expressed by ablation of the BAHD1 gene in embryos.

2016-03-15 | E-GEOD-53442 | biostudies-arrayexpress

Transcriptome analysis of whole brain tissue from Bahd1+/+ (WT) and Bahd1-/- (KO) mouse embryos (stage E16.5)

Project description:Transcriptome analysis of whole brain tissue from Bahd1+/+ (WT) and Bahd1-/- (KO) mouse embryos (stage E16.5)

| PRJNA548390 | ENA

Transcriptome analysis of half-brain tissue from Bahd1+/+ (WT) and Bahd1-/- (KO) mice (about 70 weeks old)

Project description:Comparisons of brain gene expression profiles of Bahd1-KO mice to those of wild-type littermate mice

2020-05-21 | GSE132253 | GEO

Global transcriptome analysis of different stages of preimplantation embryo development in river buffalo.

Project description:BackgroundWater buffalo (Bubalus bubalis) are divided into river buffalo and swamp buffalo subspecies and are essential livestock for agriculture and the local economy. Studies on buffalo reproduction have primarily focused on optimal fertility and embryonic mortality. There is currently limited knowledge on buffalo embryonic development, especially during the preimplantation period. Assembly of the river buffalo genome offers a reference for omics studies and facilitates transcriptomic analysis of preimplantation embryo development (PED).MethodsWe revealed transcriptomic profile of four stages (2-cell, 8-cell, Morula and Blastocyst) of PED via RNA-seq (Illumina HiSeq4000). Each stage comprised three biological replicates. The data were analyzed according to the basic RNA-seq analysis process. Ingenuity analysis of cell lineage control, especially transcription factor (TF) regulatory networks, was also performed.ResultsA total of 21,519 expressed genes and 67,298 transcripts were predicted from approximately 81.94 Gb of raw data. Analysis of transcriptome-wide expression, gene coexpression networks, and differentially expressed genes (DEGs) allowed for the characterization of gene-specific expression levels and relationships for each stage. The expression patterns of TFs, such as POU5F1, TEAD4, CDX4 and GATAs, were elucidated across diverse time series; most TF expression levels were increased during the blastocyst stage, during which time cell differentiation is initiated. All of these TFs were involved in the composition of the regulatory networks that precisely specify cell fate. These findings offer a deeper understanding of PED at the transcriptional level in the river buffalo.

| S-EPMC6894430 | biostudies-literature

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