Transcriptomics

Dataset Information

0

Modeling Human Cancer-induced Cachexia (Mouse)


ABSTRACT: Cachexia is a wasting syndrome characterized by pronounced skeletal muscle loss. In cancer, cachexia associates with increased morbidity and mortality and decreased treatment tolerance. Although advances have been made in understanding the mechanisms of cachexia, translating these advances to the clinic has been challenging. One reason for this shortcoming may be the current animal models that fail to fully recapitulate the etiology of human cancer-induced tissue wasting. Because pancreatic ductal adenocarcinoma (PDA) presents with a high incidence of cachexia, we engineered a mouse model of PDA, that we named KPP. KPP mice, similar to PDA patients, progressively lose skeletal and adipose mass as a consequence of their tumors. In addition, KPP muscles exhibit a similar gene ontology to cachectic patients. We envision the KPP model will be a useful resource for advancing our mechanistic understanding and ability to treat cancer cachexia.

ORGANISM(S): Mus musculus

PROVIDER: GSE133524 | GEO | 2019/08/06

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2019-08-06 | GSE133523 | GEO
2021-11-23 | E-MTAB-11094 | biostudies-arrayexpress
2016-05-01 | GSE80081 | GEO
2016-05-01 | GSE80080 | GEO
2014-01-10 | E-GEOD-51931 | biostudies-arrayexpress
2018-09-28 | GSE120593 | GEO
2024-10-08 | GSE278396 | GEO
2024-10-01 | GSE278013 | GEO
2021-07-14 | GSE173250 | GEO
2019-12-03 | GSE130563 | GEO