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Effects of entero-gastro-anastomosis (EGA) surgery in ob/ob mice on pancreatic islet gene expression

ABSTRACT: Bariatric surgical techniques are known to cause weight loss and diabetes remission to varying degrees in severly obese patients. However, the mechanisms involved in the restoration of beta-cell function remain to be uncovered. In this study, the leptin-deficient ob/ob mouse was used as a model to investigate the effect of EGA bariactric surgery on pancreatic islet gene expression.

ORGANISM(S): Mus musculus

PROVIDER: GSE133577 | GEO | 2020/08/05

REPOSITORIES: GEO

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Effects of entero-gastro-anastomosis (EGA) surgery in ob/ob mice on pancreatic islet miRNA expression

Project description:Bariatric surgical techniques are known to cause weight loss and diabetes remission to varying degrees in severly obese patients. However, the mechanisms involved in the restoration of beta-cell function remain to be uncovered. In this study, the leptin-deficient ob/ob mouse was used as a model to investigate the effect of EGA bariactric surgery on pancreatic islet miRNA expression.

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