Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-seq in putamen of Parkinson's disease patients

ABSTRACT: We performed RNA-seq on total RNA from tissue samples from putamen of the brain from Parkinson's disease patients.

ORGANISM(S): Homo sapiens

PROVIDER: GSE134390 | GEO | 2020/02/01

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

RNA-seq in putamen of Parkinson's disease patients

Project description:RNA-seq in putamen of Parkinson's disease patients

| PRJNA555099 | ENA

Transcriptomic profiling of substantia nigra and putamen in Parkinson’s disease

Project description:We report RNA sequencing results of human substantia nigra and putamen samples from Parkinson's disease patients and controls. Each substantia nigra sample is the result of pooling brain tissue from two individuals with the same , while each putamen sample is the result of pooling brain tissue from three individuals. We found 354 differentially expressed genes (DEGs) in the SN of PD patients compared to age-matched controls, while we observed 261 DEGs in the putamen samples. The top-enriched pathways from the SN were associated with “protein folding” and “neurotransmitter transport”, and the putamen DEGs with “synapse organization”. In summary, our data confirms the key role of protein folding and neuronal degeneration in the pathology of PD, and highlights new genes and pathways that have not yet been explored in the context of PD.

2020-09-02 | GSE136666 | GEO

RNA-seq in putamen of Multiple system atrophy patients

Project description:We performed RNA-seq on total RNA from tissue samples from putamen of the brain from Multiple system atrophy patients.

2020-02-01 | GSE134472 | GEO

Transcriptional analysis of multiple brain regions in Parkinson's disease

Project description:Transcriptional analysis of multiple brain regions in Parkinson's disease supports the involvement of specific protein processing, energy metabolism, and signaling pathways, and suggests novel disease mechanisms. This SuperSeries is composed of the following subset Series: GSE20168: Transcriptional analysis of prefrontal area 9 in Parkinson's disease GSE20291: Transcriptional analysis of putamen in Parkinson's disease GSE20292: Transcriptional analysis of whole substantia nigra in Parkinson's disease Refer to individual Series

2010-03-23 | E-GEOD-20295 | biostudies-arrayexpress

circRNAs in human brains of Parkinson's disease

Project description:total RNA sequencing of Parkinson's disease 3 regions of human brain

2020-06-26 | GSE133101 | GEO

Gene Expression in the Blood of Parkinson's Disease Patients

Project description:Peripheral blood was collected from 18 Parkinson's Disease (PD) patients and 12 healthy controls (Ctrls). Total RNA was isolated and hybridized onto Affymetrix Exon_ST1 arrays to find in PDs versus controls: 1) genes that are differentiallly expressed and 2) genes with differential exonic expression (alternative splicing).

2010-02-04 | GSE18838 | GEO

Expression analysis of laser-dissected SNpc neurons in Parkinson's disease

Project description:Genome-wide transcriptome analysis of expression changes in laser-dissected SNpc neurons from Parkinson's disease brain tissue versus control brain tissue. Post-mortem brain expression analysis performed in 10 PD brain samples and 8 control brain samples.

2010-02-22 | E-GEOD-20141 | biostudies-arrayexpress

Expression analysis of dissected Globus Pallidus interna in Parkinson's disease

Project description:Genome-wide transcriptome analysis of expression changes in Globus Pallidus interna (GPi) from Parkinson's disease brain tissue versus control brain tissue. Post-mortem brain expression analysis performed in 10 PD brain samples and 10 control brain samples.

2010-02-22 | E-GEOD-20146 | biostudies-arrayexpress

Whole transcriptome profiles of different brain regions from a Chlorocebus sabaeus model of Parkinson's disease with and without human parthenogenetic stem cell derived neural stem cell transplantation.

Project description:RNAseq was performed on caudate, putamen, and substantia nigra samples from animals treated with MPTP to induce a Parkinson's-like condition, and then transplanted with hpNSCs or control buffer. The goal of the study was to determine if there were any difference in gene expression caused by the transplanted cells.

2016-03-05 | GSE78921 | GEO

Epigenome analysis of Parkinson's disease and control samples from the Systema Genomics Parkinson's disease (SGPD) consortium

Project description:Genome wide DNA methylation association analysis of Parkinson's disease and control samples. The Illumina Infinium 450k Human DNA methylation Beadchip was used to obtain DNA methylation profiles across approximately 450,000 CpGs in blood samples. Samples included 1001 Parkinson's disease cases and 973 controls.

2020-02-17 | GSE145361 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data