Genomics

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Molecular mechanisms of transcriptional regulation by the nuclear zinc-finger protein ZFAT in HEK293 cells

ABSTRACT: ZFAT is a nuclear protein that harbors putative DNA-binding domains. Studies in mice have shown that ZFAT plays a critical role in survival and differentiation in T cells. However, molecular mechanisms whereby ZFAT regulates gene expression programs in human cells remain poorly unknown. We here identify the direct target genes of ZFAT in HEK293 human embryonic kidney cells through combination of chromatin immunoprecipitation with sequencing and transcriptional profiling.

ORGANISM(S): Homo sapiens

PROVIDER: GSE134612 | GEO | 2020/09/14

REPOSITORIES: GEO

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