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Molecular mechanisms of transcriptional regulation by the nuclear zinc-finger protein Zfat in T cells

ABSTRACT: ZFAT is a nuclear protein that harbors putative DNA-binding domains. Studies in mice have shown that ZFAT plays a critical role in survival and differentiation in T cells. However, molecular mechanisms whereby ZFAT regulates gene expression programs in T cells remain poorly unknown. We here identify the direct target genes of ZFAT in thymocytes through combination of chromatin immunoprecipitation with sequencing and transcriptional profiling.

ORGANISM(S): Mus musculus

PROVIDER: GSE83380 | GEO | 2016/09/01

SECONDARY ACCESSION(S): PRJNA325737

REPOSITORIES: GEO

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