Transcriptomics

Dataset Information

0

Gene Expression Analysis of ARC (NSC 188491) Treated MCF7 cells


ABSTRACT: ARC (NSC 188491, SMA-491), 4-amino-6-hydrazino-7-beta-d-ribofuranosyl-7H-pyrrolo-(2,3-d)-pyrimidine-5-carboxamide, is a nucleoside analog with profound in vitro anti-cancer activity. First identified in a high-throughput screen for inhibitors of p21 mRNA expression, subsequent experiments showed that ARC also repressed expression of hdm2 and survivin, leading to its classification as a global inhibitor of transcription 1. The following Hu U133 plus 2.0 arrays represent single time point (24 hour) gene expression analysis of transcripts altered by ARC treatment. Arrays for the other compounds (sangivamycin and doxorubicin) are included as comparators.

ORGANISM(S): Homo sapiens

PROVIDER: GSE13477 | GEO | 2008/11/11

SECONDARY ACCESSION(S): PRJNA110155

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2008-11-15 | E-GEOD-13477 | biostudies-arrayexpress
2017-10-19 | PXD007283 | Pride
2023-07-20 | PXD039612 | Pride
2021-06-22 | GSE116161 | GEO
2021-06-01 | GSE144670 | GEO
2024-08-10 | GSE249564 | GEO
2023-02-09 | MSV000091238 | MassIVE
2015-08-12 | E-GEOD-71937 | biostudies-arrayexpress
2018-10-01 | GSE104515 | GEO
| S-EPMC2651907 | biostudies-literature